Design, Development and optimization of chronomodulatedPulsincap delivery system of Valsartan
Keywords:Chronothepary, Valsartan, hypertension, Pulsatile capsule, 32 Full factorial design
Aim of the present study was to formulate, evaluate and optimize the Pulsincap delivery system of valsartan used for treatment of hypertension, based on the chronotherapeutic approach. The prepared pulsincap system consist of immediate release tablet sealed inside formaldehyde treated insoluble capsule body by hydrogel plug composed of polymer HPMC K15M and guar gum. The formulation produced was targeted for the preparation of time controlling pulsatile formulation to delivery drug to site and time controlling for enhancing the bioavailability of drug, so preliminary batches were prepared to study the effect of concentration of HPMC K15M and guar gum on the lag time of the drug release. Optimization of hydrogel plug was carried out by employing 32 full factorial design using Design expert 7 Software.
How to Cite
Asian Pacific Journal of Health Sciences applies the Creative Commons Attribution (CC-BY) license to published articles. Under this license, authors retain ownership of the copyright for their content, but they allow anyone to download, reuse, reprint, modify, distribute and/or copy the content as long as the original authors and source are cited. Appropriate attribution can be provided by simply citing the original article.