Chronotherapeutic drug delivery systems

Abstract

Chronobiology is the study of biological rhythms. A lot of diseases have been found that have shown rhythm in their symptoms and severity. For the treatment of such diseases, the timing of drug administration has to be matched with circadian rhythms of the disease and such treatment is called chronotherapy. If the symptoms of a disease display circadian variation drug release should also vary over time. The drug delivery systems are designed to release the drug within the short period of time, immediately after a predetermined lag time. As the name suggests, these systems are meant for chronotherapy, treatment of those diseases that are caused due to circadian changes in the body. Chronotherapeutic systems are developed when zero-order drug release is not desired. Present review of chronotherapeutic gives a comprehensive emphasis on potential disease targets, revisits the existing technologies at hand and addresses the theoretical approaches to emerging the target based on specific molecules.