GASTRORETENTIVE DRUG DELIVERY SYSTEM - A MINI REVIEW

Abstract

Oral delivery of drugs is by far the most preferable route of drug delivery. This route has high patient acceptability, primarily due to ease of administration. Effective oral drug delivery depend upon the factors such as gastric emptying process, gastrointestinal transit time of the dosage form ,drug release from the dosage form, and site of absorption of drug. In the recent years, scientific and technological advancement have been made in the research and development of gastroretentive drug delivery system. Henceforth a wide spectrum of dosage form have been developed for the drugs which have narrow absorption window, unstable at intestinal pH , soluble in acidic pH and have site of action specific to stomach.The purpose of writing this review was to investigate, compile and present the recent as well as past literatures in more concise way with special focus on approaches which are currently utilized in the prolongation of gastric residence time. These includes floating system, swelling and expanding system, bio/mucoadhesive system, high density system and other delayed gastric emptying devices. The present review addresses briefly about the classification, formulation consideration for GRDDS, factors controlling gastric retention, merits , demerits and applications of gastroretentive drug delivery systems.