COMPARISON OF SERUM TESTOSTERONE AND PROGESTERONE LEVELS IN SURGICAL AND NATURAL MENOPAUSE

Abstract

Background: Natural menopause is a physiological process which occurs around the age of 45 – 55 years. Surgical menopause is not physiological, occurs through an operative procedure which leads to sudden hormonal imbalances. Both the groups whether natural or surgical menopause experience hot flushes and mood swings, but this happens gradually in natural menopause and suddenly in surgical menopause. These symptoms may be correlated to the sudden hormonal imbalances
Aim: To study and compare hormonal levels of Progesterone and Testosterone in Surgical and Natural menopause
Settings and Design: Prospective Study
Methods and Material: 50 women (cases) belonging to surgical menopausal group and 50 women (controls) were belonging to Natural menopausal group.
The hormonal parameters (Progesterone and Testosterone) were measured by Solid Phase Competitive Chemilumniscent Enzyme Immunoassay.
Statistical analysis used: Student’s t-test was used to compare mean serum concentrations of Progesterone. Mann - Whitney U Rank Test was used to compare mean testosterone values
Diagramatic Representation : 1] Dot – Plot graphs were used to show significance as per results of t – test.
2] Bar diagrams were used to show mean values of various parameters of this study in surgical and natural menopause
Results: The mean level of progesterone hormone in study group was found to be 0.71±0.57 while that in control group was 2.074±0.42. Mann- Whitney U Rank Test was used to compare mean testosterone values which showed significant difference between both the groups of surgical and natural menopause.
Conclusion: In natural menopause the hormonal imbalance occurs gradually over a period of time but in surgical menopause the hormonal levels change abruptly. These sudden changes in the hormonal level may be responsible for severe hot flushes, headaches, mood swings and atherosclerosis.